On the mechanism of inducing protection of the adrenal cortex against injury from 7,12-dimethylbenz(a)anthracene. I. Effects of inducers on benzpyrene hydroxylase activity.
نویسندگان
چکیده
Benzpyrene (BP) hydroxylase activity in the liver, small intestine, adrenal, and mammary gland of normal rats has been quantitatively assayed. There was only a very small amount of enzyme activity in the mammary gland. Administration of 3methylcholanthrene (3-MC) induced a marked increase in BP hydroxylase activity in the liver and intestine, but was without effect on the enzyme level in the mammary gland and the adre nals. Mammary gland and adrenals are not sites for hydroxylation of polycyclic aromatic hydrocarbons. The capacities of polycyclic aromatic "protectors" and inactive
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ورودعنوان ژورنال:
- Cancer research
دوره 26 5 شماره
صفحات -
تاریخ انتشار 1966